Deno

JavaScript's interpreted, single-threaded nature imposes performance limits. While improvements via V8, Deno, and WebAssembly have helped, JavaScript is still not suitable for high-performance, multithreaded workloads like 3D simulations or large-scale numerical computing.

Developers must maintain package compatibility across multiple package managers (npm, pnpm, yarn) and JavaScript runtimes (Node, Deno, Bun), significantly complicating maintenance and distracting from security concerns.

Prisma does not officially support the Deno JavaScript runtime, limiting options for developers building Deno applications that need database access.